The LaVoie Lab

est. 2006

 
 

The LaVoie lab is a part of the Ann Romney Center for Neurologic Diseases in the Department of Neurology at Brigham and Women's Hospital and Harvard Medical School.


The LaVoie lab is primarily interested in the etiology of Parkinson's disease, a neurologic disorder affecting more than 1 million Americans today. There are several inherited forms of Parkinson's disease, and while these are very rare, we study the genetic forms of the disease in an effort to uncover the earliest molecular causes of the more common, sporadic forms of Parkinson's disease.


 

Welcome to the LaVoie Lab Website

LaVoie Lab News:

Jason’s latest paper was recently accepted in Neurobiology of Disease.


Sam Falkson, a research technician in the lab, was just named a 2017 Fulbright Scholar. We are very proud of this fantastic honor!


Dr. LaVoie is now the Editor-in-Chief of the Elsevier Journal Brain Research, which has served the international neuroscience community for over 50 years.



Key Publications:


Schapansky et al. Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons (2017). Neurobiology of Disease, in press.


LaVoie MJ. (2015) Career building as a Neuroscientist at a research hospital. Annals of Neurology 77(3):367-70.


Charan RA, Johnson BN, Zaganelli S, Nardozzi JD, LaVoie MJ. Inhibition of Bax translocation to the mitochondria is a central function of parkin (2014).  Cell Death Dis, 5:e1313.


Schapansky J, Nardozzi JD, Felizia F, LaVoie MJ. (2014) Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.  Human Molecular Genetics 23(16):4201-12.


Schlehe JS, Journel MS, Taylor KP, Amodeo KD, LaVoie MJ. The Mitochondrial Disease Associated Protein Ndufaf2 Is Dispensable For Complex-1 Assembly But Critical For The Regulation of Oxidative Stress.  Neurobiology of Disease, 2013; 58:57-67.


Johnson BN, Berger AK, Cortese GP, LaVoie MJ. The Ubiquitin E3 Ligase Parkin Regulates the Apoptotic Function of Bax.  PNAS, 2012;109:6283-8.