The LaVoie Lab

est. 2006


The LaVoie lab is a part of the Ann Romney Center for Neurologic Diseases in the Department of Neurology at Brigham and Women's Hospital and Harvard Medical School.

The LaVoie lab is primarily interested in the etiology of Parkinson's disease, a neurologic disorder affecting more than 1 million Americans today. There are several inherited forms of Parkinson's disease, and while these are very rare, we study the genetic forms of the disease in an effort to uncover the earliest molecular causes of the more common, sporadic forms of Parkinson's disease.


Welcome to the LaVoie Lab Website

LaVoie Lab News:

Sam Falkson, a research technician in the lab, was just named a 2017 Fulbright Scholar. We are very proud of this fantastic honor!

Dr. LaVoie is now the Editor-in-Chief of the Elsevier Journal Brain Research, which has served the international neuroscience community for over 50 years.

Jason Schapansky, PhD received grants this year from the Harvard NeuroDiscovery Center and American Parkinson’s Disease Association.

Recent Key Publications:

Charan RA & LaVoie MJ. Pathologic and therapeutic implications for the cell biology of parkin.  Mol Cell Neurosci 66(A):62-71.

LaVoie MJ. (2015) Career building as a Neuroscientist at a research hospital. Annals of Neurology 77(3):367-70.

Ashrafti G, Schlehe JS, LaVoie MJ, Schwarz TL. (2014) Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and parkin.  J Cell Biol. 206(5)655-70.

Charan RA, Johnson BN, Zaganelli S, Nardozzi JD, LaVoie MJ. Inhibition of Bax translocation to the mitochondria is a central function of parkin.  Cell Death Dis, Jul 3;5:e1313.

Schapansky J, Nardozzi JD, Felizia F, LaVoie MJ. (2014) Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.  Human Molecular Genetics 23(16):4201-12.

Schlehe JS, Journel MS, Taylor KP, Amodeo KD, LaVoie MJ. The Mitochondrial Disease Associated Protein Ndufaf2 Is Dispensable For Complex-1 Assembly But Critical For The Regulation of Oxidative Stress.  Neurobiology of Disease, 2013; 58:57-67.

Johnson BN, Berger AK, Cortese GP, LaVoie MJ. The Ubiquitin E3 Ligase Parkin Regulates the Apoptotic Function of Bax.  PNAS, 2012;109:6283-8.