The Center for Neurologic Diseases
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Research

Parkinson's Disease

  1. The Potential Role of Dopamine as a Neurotoxin

  2. The Function of Parkin in Mitochondrial Physiology and
    Pathophysiology

  3. The Study of LRRK2 Phosphorylation and Regulation

Alzheimer's Disease

  1. The Physiological Role of Gamma-Secretase mediated Proteolysis of Jagged

  2. The Role of Aph-1 in Gamma-Secretase Assembly and Function

Key PD Publications

  • LaVoie MJ, Cortese GC, Ostaszewski BL, Schlossmacher MG. The Effects of Oxidative Stress on Parkin and other E3 Ligases. J Neurochem. 2007;103(6):2354-68.
  • LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe DJ (2005). Dopamine covalently modifies and functionally inactivates parkin. Nature Medicine 11(11):1214-1221.
  • Baulac S, LaVoie MJ, Strahle J, Schlossmacher MG, Xia W. Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain. Mol Cell Neurosci. 2004; 27(3):236-46.
  • LaVoie MJ, Card JP, Hastings TG. Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity. Exp Neurol. 2004;187(1):47-57.
  • LaVoie MJ and Hastings TG. Peroxynitrite- and nitrite-induced oxidation of dopamine: implications for nitric oxide in dopaminergic cell loss. J Neurochem. 1999;73(6):2546-54.
  • LaVoie MJ, Hastings TG (1999). Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine. J Neurosci 19:1484-91.

 

Key AD Publications

  • Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A. 2003;100(11):6382-7.
  • LaVoie MJ and Selkoe DJ. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem. 2003;278(36):34427-37.
  • LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem. 2003;278(39):37213-22.