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LaVoie Lab Publications

  • Amin P, Florez M, Najafov A, Pan H, Geng J, Ofengeim D, Dziedzic AS, Wang H, Barrett VJ, Ito Y, LaVoie MJ, Yuan JY. Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFa-mediated apoptosis. PNAS, 2018, Epub ahead of print.
  • Schapansky J, Khasnavis S, DeAndrade MP, Nardozzi JD, Falkson SR, Boyd JD, Sanderson JB, Bartels T, Melrose HL, LaVoie MJ. Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble alpha-synuclein in neurons. Neurobiology of Disease, Epub 2017, 11:26-35.
  • Shlevkov E, Kramer T, Schapansky J, LaVoie MJ, Schwarz TL. Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. PNAS, 2016, 113(41):E6097-E6106.
  • Charan RA & LaVoie MJ.  Pathologic and Therapeutic Implications for the Cell Biology of Parkin.  Mol Cell Neuro, 2015, 66(A) 62-71.
  • LaVoie MJ. (2015) Career building as a Neuroscientist at a research hospital. Annals of Neurology 77(3):367-70.
  • Schapansky J, Nardozzi JD, LaVoie MJ. The Complex Relationships Between Microglia, Alpha-Synuclein, and LRRK2 in Parkinson’s Disease. Neuroscience, 2014, pii: S0306-4522(14)00800-8.
  • LaVoie MJ. Career Building as a Neuroscientist at a Research Hospital.  Annals of Neurology, 77(3):367-70.
  • Ashrafti G, Schlehe JS, LaVoie MJ, Schwarz TL. Mitophagy of Damaged Mitochondria Occurs Locally in Distal Neuronal Axons and Requires PINK1 and Parkin.  J Cell Biol, 2014, 206(5): 655-70.
  • Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ. Genetic deletion of the GATA1-regulated protein alpha-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.  Am J Hematol, 2014, 89(10)974-7.
  • Charan RA, Johnson BN, Zaganelli S, Nardozzi JD, LaVoie MJ. Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. Cell Death & Disease, 2014; 5:e1313.
  • Schapansky J, Nardozzi JD, Felizia F, LaVoie MJ. (2014) Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.  Hum Mol Genet, in press.
  • Schlehe JS, Journel MS, Taylor KP, Amodeo KD, LaVoie MJ. The Mitochondrial Disease Associated Protein Ndufaf2 Is Dispensable For Complex-1 Assembly But Critical For The Regulation of Oxidative Stress.  Neurobiology of Disease, 2013; 58:57-67.
  • Johnson BN, Charan R, LaVoie MJ. Recognizing the Cooperative and Independent Mitochondrial Functions of Parkin and PINK1.  Cell Cycle, 2012; 11(15) 2775-6.
  • Johnson BN, Berger AK, Cortese GP, LaVoie MJ. The Ubiquitin E3 Ligase Parkin Regulates the Apoptotic Function of Bax.  PNAS, 2012; 109:6283-8.
  • Wang X, Winter D, Ashrafi G, Schlehe JS, Wong YL, Selkoe DJ, Rice S, Steen J, LaVoie MJ, Schwarz TL. PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility. Cell, 2011; 147:893-906.
  • Bosco DA, LaVoie MJ, Petsko GA, Ringe D.  Proteostasis and Movement Disorders: Parkinson’s Disease and Amyotrophic Lateral Sclerosis, in Protein Homeostasis, 2011. Cold Spring Harbor Laboratory Press.
  • Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin  SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG.  Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.  J Neural Trans, 2011; 118(5) 795-808.
  • Berger Z, Smith KA, LaVoie, MJ.  Membrane localization is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation, Biochemistry, 2010; 49 (26); 5511-23.
  • Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ. APH-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.  J Biol Chem, 2010; 285; 11378-91.
  • Berger AK, Cortese GP, Amodeo KD, Weihofen A, Letai A, LaVoie MJ.  Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release. Hum Mol Genet, 2009; 18; 4317-28.
  • Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, LaVoie MJ, Slack RS, RAO Y, Zhang Z, Lu B, Haque ME, Park DS.  Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson’s disease. Hum Mol Genet, 2009; 18; 4390-404.
  • LaVoie MJ, Cortese GP, Ostaszewski BL, Schlossmacher MG.  The effects of oxidative stress on parkin and other E3 ligases.  J Neurochem, 2007; 103 (6) ; 2354-68.
  • LaVoie MJ, Ostaszewski B, Weihofen A, Schlossmacher MG, Selkoe DJ. (2005) Dopamine covalently modifies and functionally inactivates parkin.  Nat Med, 2005; 11: 1214-1221.